Interface interactions between biological vesicles and inorganic surfaces of biomaterials using atomic force microscopy

Authors

  • Federico Solera Laboratorio Nacional de Nanotecnología. Centro Nacional de Alta Tecnología. Consejo nacional de Rectores. Costa Rica.
  • José Vega Baudrit Laboratorio Nacional de Nanotecnología. Centro Nacional de Alta Tecnología. Consejo nacional de Rectores. Costa Rica. Laboratorio de Polimeros. Escuela de Química. Universidad Nacional de Costa Rica.
  • Sergio Madrigal Laboratorio de Polímeros. Escuela de Química. Universidad Nacional Costa Rica.
  • Arlene Loria Instituto de Investigaciones Farmacéuticas. Facultad de Farmacia. Universidad de Costa Rica.

Keywords:

Interface, biological vesicles, biomaterials, atomic, force microscopy, liposome

Abstract

Interface interactions between biological vesicles and inorganic surfaces of biomaterialsusing atomic force microscopy.

Abstract

Interface incompatibilities in the interaction between biological microparticles that normally circulate in theblood and the surface of biomaterials implants are normally associated with subsequent rejection reactionsby the immune system. This requires an explanatory model for the behavior observed at the interface ofliposomes and platelets in contact with biomaterials and inorganic surfaces. Thus, allowing the analysis ofthe relationship between the ionic balance of surface forces of attraction between liposome-surface/degreeof deformation and change in the surface properties of liposomal nanoparticles absorbed by the surfacemodification of liposomes with biopolymers such as chitosan. Progress has been made in understanding thedynamics of interfaces for consistency of different lipids vesicles as a model and found that the biopolymercoating of lipid vesicles with chitosan provides better physical stability and an increase in the interface betweenbiomaterials and biomimetic inorganic nanoparticles.

Key words:

Interface, biological vesicles, biomaterials, atomic force microscopy, liposome.

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